IndraLab

Statements

Chloroquine inhibits STING1. 5 / 5
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"Degradation of STING occurred in the lysosomal compartment since chloroquine, which inhibits lysosomal degradation, prevented STING degradation (XREF_SUPPLEMENTARY)."
24119841
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"Brefeldin A, but not chloroquine, blocked STING trafficking, indicating that STING locates from the ER via the Golgi to vesicles in the perinuclear region (XREF_SUPPLEMENTARY)."
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"On the other hand, we treated cells with chloroquine to inhibit autophagy in STING‐EVs recipient L929 cells."
36946680
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"For example, chloroquine attenuated the pro-inflammatory (Tnf, Cd68, Ccl2) and IFN-I (Tmem173, Irf7) profiles of cortical RNA."
37937831
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"Chloroquine, a lysosomal inhibitor which reportedly prevents STING degradation, did not block STING trafficking, confirming that STING degradation occurs after translocation (XREF_FIG)."
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