IndraLab

Statements

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"USP18 promotes PC cell growth in vitro and in vivo."
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"USP18 promotes PC cell growth by facilitating cell cycle progression."
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"USP18 contributes to the progression of pancreatic cancer through enhancing the Notch1-c-Myc axis USP18 has been reported to interact with different substrates to exert its effects [ 16-18 ] ."
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"To further validate that USP18 mediated the growth of PC cells by regulating c-Myc, we first increased the expression of c-Myc in USP18 knockdown PC cells and then measured the USP18 and c-Myc protein expression levels and cell proliferation."
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"( G ) Proposed model by which USP18 promotes PC progression by modifying Notch1 / c-Myc axis ."
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"Overall , these results demonstrated that USP18 contributes to the progression of pancreatic cancer and is dependent on the Notch1 / c-Myc signalling pathway ( Figure 7G ) ."
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"Moreover , we found that USP18 promoted pancreatic cancer progression via upregulation of Notch-1-dependent c-Myc ."
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