IndraLab

Statements

Mexiletine activates SCN5A. 3 / 3
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"A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine."
12123767
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"Patients included in the study were referred to the Molecular Cardiology Division at ICS Maugeri Hospital in Pavia, Italy Patients were genotyped and identified as carriers of a DNA variant in the coding sequence of the SCN5A gene and they were treated with mexiletine."
30566038
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"Of note, a severe IBS-C case with a highly penetrating SCN5A loss-of-function mutation could be successfully treated with mexiletine, a drug known to restore Na V 1.5 channel function."
26873717