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DauA inhibits KCNH2. 6 / 6
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"We found that Dau inhibits I HERG in the open and inactivated states and induces a marked shift of HERG activation curves towards more negative potentials.Experiments were performed on a HEK293 cell l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Taken together, Dau inhibits HERG channels predominantly in the open and inactivated state rather than in the closed state.In this study, we have examined the pharmacological effects of Dau on the ele[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We found that Dau directly inhibited I HERG in a concentration dependent manner with an IC 50 of 3.5 muM, indicating that Dau has the potential to induce APD prolongation."
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"Because Dau inhibits I Ca, I Ks, I Kl and HERG, the effect would result in a lengthening of the refractory period and a decrease of cardiac excitability, thus contributing to its anti-arrhythmic effec[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In the fully activated I - V relationships, where the full conductance of the HERG channels was induced, Dau inhibited I HERG ~ 40% even at a hyperpolarizing potential of -100 mV."
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"HERG channel may be one of the key target sites explaining both the therapeutic effects and the potential cardiotoxicity with these herbs.In summary, we have shown that Dau directly blocks HERG channe[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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