IndraLab

Statements

KCNA3 phosphorylates BECN1 on S90. 2 / 2
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sparser
"Taken together, these data indicate that MK2 and MK3 directly phosphorylate Beclin 1 S90 in vitro, and that MK2-like kinase activity also mediates starvation-induced Beclin 1 S90 phosphorylation in cultured cells."
25693418
sparser
"Given the requirement of the Beclin 1 S90 site for the tumor suppressor activity of Beclin 1, it will be interesting to determine whether the lack of MK3-dependent Beclin 1 S90 phosphorylation contributes to the pathogenesis of small cell lung carcinomas that commonly harbor deletions in MK3 ( xref ) or of other cancers with frequent heterozygous loss of MK3 such as invasive breast carcinomas, ovarian carcinomas, lung adenocarcinomas and lung squamous cell carcinomas ()."
25693418