IndraLab

Statements

OTUD4 inhibits GSDME. 2 / 2
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"In brief, these data further confirm that OTUD4 stabilizes and upregulates GSDME and that downregulation of OTUD4 inhibits GSDME-dependent pyroptosis, leading to radioresistance and poor prognosis in NPC."
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"Upregulation of OTUD4 significantly prolonged the half-life of endogenous GSDME, and silencing OTUD4 diminished the degradation half-life of GSDME in NPC cells (Fig. 5I and J)."
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