IndraLab

Statements

NAC inhibits NLRP3. 34 / 34
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"NAC blocks NLRP3 inflammasome activation by interfering with the priming step required to induce NLRP3 expression."
33816149
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"Additionally, the level of NLRP3 was lower in groups treated with NAC than in the control group."
29993180
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"The pretreatment of ROS inhibitor N-acetyl-L-cysteine ( NAC ) significantly attenuated N. caninum-induced ROS production , LDH release , IL-1beta secretion and NLRP3 expression , whereas N. caninum proliferation was notably increased ."
32891167
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"N-acetyl-l-cysteine (NAC), a reductant, inhibits NLRP3 activation in different models XREF_BIBR XREF_BIBR XREF_BIBR."
28084303
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"Furthermore, CCCP or NAC (ROS inhibitor) treatment could inhibit ERK signal, Nlrp3 inflammasome, and cytokine production, while promote p38 signal in N. caninum -infected macrophages."
35355995
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"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."
29675433
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"Notably, NAC effectively blocked the GCN5L1 overexpression mediated upregulation of NLRP3, caspase 1, IL18, and IL1b (XREF_FIG)."
33680286
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"N-Acetyl-L-cysteine (NAC) administration also inhibited oxidative stress and activation of the calpain system and the NLRP3 inflammasome."
35498131
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"Meanwhile, NAC pretreatment inhibited ZnO-NPs-induced activation of NF-kappaB and NLRP3 inflammasome."
28870124
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a in human clinical trials."
32504923
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"NAC significantly abrogated PrP106-126-induced NALP3 and ASC upregulation; the mRNA levels of NALP3 and ASC significantly decreased after NAC treatment in PrP106-126-treated microglia and dropped to 68% and 54%, respectively, of the levels seen in microglia treated with PrP106-126 only."
22531291
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"In this study, NAC significantly diminished IL-1beta secretion triggered by mycobacterial infection, suggesting that ROS are involved in M. kansasii induced NLRP3 inflammasome activation; however the source of ROS is currently unknown."
22558425
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"In vitro , N-acetylcysteine ( NAC ) inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression , in MOVAS cells treated with TNF-alpha ."
35217818
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a."
| PMC
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"High concentrations of NAC have been reported to inhibit NLRP3 activation."
23809161
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"The addition of NAC prior to BSA exposure prevented Nlrp3 upregulation and co-localisation with fissured mitochondria."
25281528
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"The ROS inhibitor , N-acetyl-l-cysteine ( NAC ) , significantly reduced IL-1beta production , and blocked NLRP3 and ASC upregulation after exposure to PrP106-126 in murine microglia ( Shi et al ., 2012 ) ."
33776778
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"Moreover, the ROS scavenger NAC inhibited NLRP3 inflammasome activation, indicated by the decreased expression of NLRP3 (XREF_FIG), ASC (XREF_FIG), and procaspase-1 (XREF_FIG) induced by HG and H/R (XREF_FIG)."
29062465
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"These results clearly demonstrated that NAC downregulated the NLRP3 inflammasome and inhibited inflammatory responses caused by LPS."
| PMC
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"NAC similarly inhibited activation of the NLRP3 inflammasome."
32751738
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a in human clinical trials."
| PMC
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"We found that NAC inhibited the activation of NLRP3 inflammasomes to alleviate cell injury in cardiomyocytes after H/R injury in both LG and HG conditions."
29062465
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"Moreover, NAC is able to inhibit NALP3 inflammasome that lowers the inflammatory response and ROS mediated synthesis [XREF_BIBR]."
33668325
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"Anti-oxidants L-carnitine and NAC significantly suppress ROS overproduction and BRCC36 production, block caspase-8 activation, and largely reverse or restore the imbalance of activated NLRP3 and suppressed NLRP6."
28238526
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"Furthermore, the mechanism study found that PPVI could activate the NF-kappaB signaling pathway via increasing reactive oxygen species (ROS) levels in A549 and H1299 cells, and N -acetyl-L-cysteine (NAC), a scavenger of ROS, remarkably inhibited the cell death, and the activation of NF-kappaB and the NLRP3 inflammasome in PPVI treated A549 and H1299 cells."
31941010
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"NAC improved the cell viability and inhibited NLRP3 inflammasome activation."
30378301
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"ROS inhibitor NAC attenuated N. caninum induced NLRP3 inflammasome activation and increased N. caninum proliferation in PMs."
32891167
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"In the present study, we found that the ROS inhibitor NAC significantly reduced the production of IL-1beta, and blocked NALP3 and ASC upregulation after exposure to PrP106-126, suggesting a role of ROS generation in the activation of the inflammasome in PrP106-126-stimulated microglia."
22531291
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"NAC did not affect modification of IRAK1 in response to Pam3CSK4 stimulation, as evidenced by the disappearance of the IRAK1 band (XREF_FIG, lower panel), indicating that NAC inhibits NLRP3 activation downstream of IRAK1."
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"Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS)."
35437791
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"The cell-permeable reducing agent dithiothreitol and the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC) did not inhibit the hyperosmotic expression of the NLRP3 gene (XREF_FIG)."
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"The use of ROS scavenger N-acetylcysteine (NAC) partially reversed NLRP3 inflammasome activity in cells exposed to burn serum."
26576075
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"NLRP3 , ASC , and active caspase-1 , and cleaved IL-1beta protein levels were downregulated by CD36 siRNA , NOX1 siRNA , DPI , and NAC ( Figures 2 ( a ) -2 ( e ) ) ."
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"NAC, a kind of ROS inhibitor, dramatically inhibited NLRP3 inflammasome activation and decreased the secretion of mature IL-1beta."
29993180