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NAC inhibits NLRP3. 73 / 73
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"Some studies performed in oxygen–glucose-deprived rat cardiomyocyte H9C2 that was used as the cellular model for myocardial infarction, revealed that NAC suppressed the activity of NLRP3 and the activation of GSDMD and also reduced the NFκB [85]."
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"An in-vitro study using SARS-CoV-2 showed that NAC could inhibit the activation of NLRP3 inflammasome [20]."
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"NAC also reduces the activation of NLRP3 inflammasome, which is one of the first mechanisms of the innate immune response to viral infection [62]."
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"NAC blocks NLRP3 inflammasome activation by interfering with the priming step required to induce NLRP3 expression."
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"Anti-oxidants L-carnitine and NAC significantly suppress ROS overproduction and BRCC36 production, block caspase-8 activation, and largely reverse or restore the imbalance of activated NLRP3 and suppressed NLRP6."
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"The addition of NAC prior to BSA exposure prevented Nlrp3 upregulation and co-localisation with fissured mitochondria."
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"The cell-permeable reducing agent dithiothreitol and the reactive oxygen species (ROS) inhibitor N-acetyl-L-cysteine (NAC) did not inhibit the hyperosmotic expression of the NLRP3 gene (XREF_FIG)."
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"Additionally, these fibers displayed augmented activation of the NLRP3 inflammasome, accompanied by heightened ROS-dependent proximity between TXNIP and NLRP3, which was abolished by the antioxidant N-acetylcysteine (NAC)."
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"Pretreatment with ROS scavenger NAC can reverse the activation of NLRP3 inflammasome complex in Figure 8(h), suggesting that ROS plays an important role in the activation of NLRP3 inflammasome."
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"Overall, this study revealed that BUN + NAC inhibits the activation of NLRP3 by regulating miR-381, thereby alleviating ALI caused by pyroptosis-mediated inflammation."
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"NAC suppressed the formation of the NLRP3 inflammatory complex, hindered the activation of downstream functional proteins, and further inhibited IL-1β maturation and AM pyroptosis."
36876152
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"These data revealed that NAC co-treatment notably ameliorated Cd-mediated pyroptosis, suppressed NLRP3 activation, and decreased the GSDMD, cleaved caspase-1, and cleaved IL-1β levels."
36347317
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"These results clearly demonstrated that NAC downregulated the NLRP3 inflammasome and inhibited inflammatory responses caused by LPS."
| PMC
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"ROS inhibitor NAC attenuated N. caninum induced NLRP3 inflammasome activation and increased N. caninum proliferation in PMs."
32891167
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"Treatment with NAC or ddC also effectively attenuated the activation of NLRP3 inflammasome induced by SelW overexpression, suggesting that mito-ROS and mtDNA accumulation induced by the SelW/PKM2/HIF-1α axis activates the NLRP3 inflammasome, thereby mediating pyroptosis."
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"NAC was also observed to inhibit NEK7/NLRP3 activation, suggesting that NAC attenuated renal tubular epithelial cell apoptosis by reducing UA-induced oxidative stress via the NEK7/NLRP3 signaling pathway."
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"Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS)."
35437791
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"Meanwhile, the ROS scavenger NAC significantly suppressed activation of the NLRP3 inflammasome."
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1β and IL18) in vitro , and decrease plasma TNF-ɑ."
32504923
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"To confirm that vitamin D3 inhibits the TXNIP/NLRP3 inflammatory pathway by suppressing oxidative stress, HK-2 cells were cultured with the oxidative stress inhibitor NAC under different glucose concentrations."
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"Notably, NAC effectively blocked the GCN5L1 overexpression mediated upregulation of NLRP3, caspase 1, IL18, and IL1b (XREF_FIG)."
33680286
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"We found that NAC inhibited the activation of NLRP3 inflammasomes to alleviate cell injury in cardiomyocytes after H/R injury in both LG and HG conditions."
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"A previous study has suggested that Ac-YVAD-CMK, BAY11-7082, or NAC attenuate HG- and H/R-stimulated H9C2 cell injury and suppress NLRP3 inflammasome-dependent pyroptosis.170 Suppression of the NLRP3 inflammasome and ROS synthesis attenuates cell injury and pyroptosis in LPS-stimulated H9C2 cells under HG and H/R conditions.170 BAY11-7082 and NAC treatment can hinder NLRP3 inflammasome by decreasing the NLRP3, ASC, and NF-κB p65 protein expression levels in LPS and HG+H/R-stimulated H9C2 cells."
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"The results indicated that NAC and quercetin diminished the increase of NLRP3 compounds."
34688696
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"NAC improved the cell viability and inhibited NLRP3 inflammasome activation."
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"Moreover, NAC is able to inhibit NALP3 inflammasome that lowers the inflammatory response and ROS mediated synthesis [XREF_BIBR]."
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"Immunoblotting results revealed that QDs-induced NLRP3 activation was significantly abrogated by the presence of NAC and Mito-TEMPO as evidenced by the inhibition of Casp1 p20 and IL-1β production ( F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, Western blot analysis demonstrated NAC decreased the contents of NLRP3, GSDMD-T, GSDMD-N, pre-Caspase-1, cle-Caspase-1 increased by H O intervention (P<0.05, Fig. 13C–H)."
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"In both GBM cell lines, NAC attenuated the formation of the inflammatory vesicle NLRP3, resulting in a subsequent reduction in the activation of caspase 1 and GSDMD, and ultimately leading to a decrease in the inflammatory factor IL‐1β."
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"In addition, functional experiments confirmed that both ROS scavenger NAC and METTL3-ablation downregulated NLRP3, GSDMD-C, cleaved Caspase-1 and ASC to restrain pyroptotic cell death and decreased the expression levels of IL-1β, IL-18, IL-6 and TNF-α to restrain inflammatory cytokines expression in Mtb-infected macrophages."
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"NAC also inhibits the NLRP3 inflammasome."
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"ROS mainly comes from mitochondria; pretreatment with ROS scavenger NAC can reverse the activation of NLRP3 inflammasome complex in our study."
37261217
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"The pretreatment of ROS inhibitor N-acetyl-L-cysteine ( NAC ) significantly attenuated N. caninum-induced ROS production , LDH release , IL-1beta secretion and NLRP3 expression , whereas N. caninum proliferation was notably increased ."
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"The results showed that ML385 enhanced the activation of NLRP3 inflammasomes, whereas NAC suppressed the activation of NLRP3 inflammasomes."
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"WB results showed that NAC treatment further promoted the reduction of NLRP3, cle-Caspase-1, GSDMD-N, IL-1β, and IL-18 in the AngII+C75 group, while pro-Caspase-1 expression remained unchanged ( Figures 8Q–W )."
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"High concentrations of NAC have been reported to inhibit NLRP3 activation."
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a in human clinical trials."
| PMC
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"Furthermore, CCCP or NAC (ROS inhibitor) treatment could inhibit ERK signal, Nlrp3 inflammasome, and cytokine production, while promote p38 signal in N. caninum -infected macrophages."
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"NAC significantly abrogated PrP106-126-induced NALP3 and ASC upregulation; the mRNA levels of NALP3 and ASC significantly decreased after NAC treatment in PrP106-126-treated microglia and dropped to 68% and 54%, respectively, of the levels seen in microglia treated with PrP106-126 only."
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"Interestingly, antioxidant NAC could partly resist the activation of NLRP3 inflammasome and downstream inflammatory factors stimulated by high NEFA."
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"We reported previously that high glucose and lipopolysaccharide activate ROS-TXNIP-NLRP3 inflammasome signaling in GMCs, but ROS inhibitor N-acetylcysteine (NAC) could not completely inhibit the activation of NLRP3 inflammasome induced by high glucose, suggesting that there may be other pathways by which high glucose primes ROS-NLRP3 inflammasome signaling [XREF_BIBR]."
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"Thus, Bud and NAC attenuate LPS-induced alterations in proliferation, viability, apoptosis, scorching and inflammatory responses in human bronchial epithelial cells via miR-381/NLRP3."
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"NAC has also been shown to inhibit the NLRP3 inflammasome pathway (IL1beta and IL18) in vitro, and decrease plasma TNF-a."
| PMC
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"Moreover, the ROS scavenger NAC inhibited NLRP3 inflammasome activation, indicated by the decreased expression of NLRP3 (XREF_FIG), ASC (XREF_FIG), and procaspase-1 (XREF_FIG) induced by HG and H/R (XREF_FIG)."
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"Treatment with NAC or MitoTEMPO obviously diminished the activation of the NLRP3 inflammasome, indicating that the NLRP3 inflammasome was mtROS-dependent (Figures 6E,G)."
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"Bengalli et al. found that PM10 induced ROS activated NLRP3 inflammasome and consequently promoted thematuration of pro-IL-1b into bioactive IL-1b, and they also discovered that NAC significantly inhibited this PM10mediated activation of NLRP3 inflammasome and blocked IL-1b production (Bengalli et al., 2013)."
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"NAC reduced Cd induced increases in ROS, NLRP3, Caspase-1, Heme oxygenase-1(HO-1), superoxide dismutase (SOD2), and increased mitochondrial function."
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"In the present study, we found that the ROS inhibitor NAC significantly reduced the production of IL-1beta, and blocked NALP3 and ASC upregulation after exposure to PrP106-126, suggesting a role of ROS generation in the activation of the inflammasome in PrP106-126-stimulated microglia."
22531291
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"In addition, it has been shown that NAC inhibits NLRP3 activation [52]."
36498845
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"N-Acetyl-L-cysteine (NAC) administration also inhibited oxidative stress and activation of the calpain system and the NLRP3 inflammasome."
35498131
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"As shown in Fig. 4 H, both NAC and quercetin significantly attenuated the upregulation of NLRP3 and cleaved-caspase1."
34688696
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"In vitro , N-acetylcysteine ( NAC ) inhibited NLRP3 inflammasome activation and NLRP3 knockdown reduced GSDMD expression , in MOVAS cells treated with TNF-alpha ."
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"Additionally, the level of NLRP3 was lower in groups treated with NAC than in the control group."
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"Previous research, however, has revealed that while N-acetyl cysteine (NAC) suppresses NLRP3 activation by blocking ROS in wild-type macrophages stimulated with lipopolysaccharide (LPS)/silica or LPS/nigericin, caspase-1 activation is not inhibited when NLRP3 expression is uncoupled from the priming signal by stable overexpression."
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"And ROS scavenger NAC inhibited the activation of NLRP3 inflammasome characterized by a decrease of caspase-1 p10 expression and IL-1β secretion ( Fig. 5 E–G)."
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"N-acetyl-l-cysteine (NAC), a reductant, inhibits NLRP3 activation in different models XREF_BIBR XREF_BIBR XREF_BIBR."
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"In this study, NAC significantly diminished IL-1beta secretion triggered by mycobacterial infection, suggesting that ROS are involved in M. kansasii induced NLRP3 inflammasome activation; however the source of ROS is currently unknown."
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"Furthermore, the mechanism study found that PPVI could activate the NF-kappaB signaling pathway via increasing reactive oxygen species (ROS) levels in A549 and H1299 cells, and N -acetyl-L-cysteine (NAC), a scavenger of ROS, remarkably inhibited the cell death, and the activation of NF-kappaB and the NLRP3 inflammasome in PPVI treated A549 and H1299 cells."
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"NLRP3 , ASC , and active caspase-1 , and cleaved IL-1beta protein levels were downregulated by CD36 siRNA , NOX1 siRNA , DPI , and NAC ( Figures 2 ( a ) -2 ( e ) ) ."
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"Mechanistic studies indicated that the addition of N-acetylcysteine (NAC), a ROS scavenger, inhibited NLRP3 activation and attenuated pyroptosis."
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"Meanwhile, NAC pretreatment inhibited ZnO-NPs-induced activation of NF-kappaB and NLRP3 inflammasome."
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"Moreover, we also found that NAC partially reversed the facilitation of LPS on the levels of ROS, IL-1β, IL-18, TXNIP, NLRP3, ASC, and Cleaved Caspase-1 in BV-2 cells."
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"The addition of NAC or MCC950 during intracellular S. pseudintermedius infection of CCECs significantly reduced the accumulation of intracellular ROS and the activity of the NLRP3 inflammasome and inhibited the rupture of the cell membrane."
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"The results showed that NAC treatment obviously inhibited NLRP3 inflammasome triggered by psoralidin."
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"NAC also inhibited the Hcy-induced protein expression of inflammasome components, including NLRP3, cleaved Caspase-1, IL-1β, and cleaved GSDMD (Fig. 5C–G), suggesting that NLRP3 inflammasome activation was dependent on ROS generation."
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"Telmisartan as well as an anti-oxidant NAC was found to completely block the AII-induced increase in NF-κB promoter activity."
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"NAC did not affect modification of IRAK1 in response to Pam3CSK4 stimulation, as evidenced by the disappearance of the IRAK1 band (XREF_FIG, lower panel), indicating that NAC inhibits NLRP3 activation downstream of IRAK1."
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"NAC, a kind of ROS inhibitor, dramatically inhibited NLRP3 inflammasome activation and decreased the secretion of mature IL-1beta."
29993180
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"In a mouse alveolar macrophage model induced by LPS and NETs, N-acetyl-L-cysteine (NAC) prevented NLRP3 inflammasomes from undergoing deubiquitination modification by binding to DUBs."
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"NAC similarly inhibited activation of the NLRP3 inflammasome."
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"Treatment with N-acetylcysteine (NAC), a ROS scavenger, remarkably inhibited TCP particles-induced protein expressions of NLRP3 inflammasome components including NLRP3, ASC, Casp-1 p20, IL-1β and GSDM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Application of the ROS scavenger N-acetylcysteine (NAC) can significantly inhibit the activation of NLRP3 and osteocytes pyroptosis."
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"The ROS inhibitor , N-acetyl-l-cysteine ( NAC ) , significantly reduced IL-1beta production , and blocked NLRP3 and ASC upregulation after exposure to PrP106-126 in murine microglia ( Shi et al ., 2012 ) ."
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