IndraLab

Statements


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reach
"Cytotoxicity and transcriptomic data corroborated that gefitinib downregulates EGFR-regulated genes (AURKA, CCND1, c-MYC, c-FOS, and FGF19), upregulates p53 and FOXO-regulated genes, hampers cell cycle progression and cell differentiation, and promotes cell apoptosis [14]."

eidos
"Gefitinib and PD153035 strongly suppressed ERK1 / 2 and MKP1 phosphorylation as well as increases in c-Fos ( Fig. 1B-C ) but had no effect on p38 phosphorylation ( Fig. 1A , fig ."

reach
"It is clear from the data presented in XREF_FIG for the EGFSP genes, that gefitinib was unable to block the response of the EGFR, c-Fos, SOS, GRB2, JNK-1, MKK4 or RasGAP to luteolin."