IndraLab

Statements

Ajmalinium inhibits KCNH2. 8 / 8
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"Ajmaline blocked HERG currents with an IC (50) of 1.0 micromol/l in HEK cells and 42.3 micromol/l in Xenopus oocytes."
15599706
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"Ivabradine, ajmaline and mexiletine inhibited KCNH2 channel currents significantly, which may underlie their APD prolonging effects."
30947366
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"Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels : mode of action."
15599706
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"Binding of ajmaline to inactivated HERG channels may also be possible."
15599706
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"Results : Ajmaline, amiodarone, ivabradine, flecainide, quinidine, mexiletine and ranolazine inhibited the hERG channel current (I Kr) less strongly in hiPSC-CMs from the SQTS1-patient (SQT1-hiPSC-CMs) comparing with cells from the healthy donor (donor-hiPSC-CMs)."
34025432
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"Ivabradine, ajmaline and mexiletine inhibited the KCNH2 channel currents, probably underlying their APD prolonging effects."
33023024
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"Ajmaline blocked HERG channels in the open, but not in the closed states."
15599706
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"Indeed, ajmaline inhibited the hERG channel current, prolonged APD and reduced arrhythmic events in SQTS1-cells."
34025432