IndraLab

Statements

PKA phosphorylates KCNK2. 13 / 14
| 7 6 1
reach
"It has also been suggested that PKA phosphorylates TREK1 and converts it into a voltage dependent channel XREF_BIBR."
24086441
sparser
"Activation is accomplished by a direct interaction between KCNK2 and riluzole, while the inhibitory effect is indirect and mediated by PKA phosphorylation of KCNK2."
30333618
sparser
"It has also been suggested that PKA phosphorylates TREK1 and converts it into a voltage-dependent channel xref ."
24086441
reach
"Activation is accomplished by a direct interaction between KCNK2 and riluzole, while the inhibitory effect is indirect and mediated by PKA phosphorylation of KCNK2."
30333618
sparser
"PKA directly phosphorylates TRPV1 and the heat-sensitive potassium channel TREK ( xref , xref , xref ), and in both cases, this phosphorylation modulates the electrophysiological properties of the channel."
15249591
sparser
"TREK‐1 gating is inhibited by PKA phosphorylation of TREK‐1, which is facilitated by AKAP79 association (Noël et al ,  xref ), while TREK‐1 channel density on the plasma membrane is enhanced by POPDC1 (Froese et al ,  xref ; Rinné et al ,  xref )."
36254885
sparser
"Interestingly, PKA-induced phosphorylation of the mouse Ser348 residue switches TREK-1 into a voltage-gated channel, whereas PKA modification of the analogous residue in rat TREK-1, Ser333, leads to i[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19084539
reach
"In summary, RIL inhibits the phosphodiesterase E provoking an increase of the cAMP concentration leading to the activation of protein kinase A, which phosphorylates TREK1 channels reducing their activity (Duprat et al., 2000)."
30964046
reach
"Although 2P channels contain no recognised voltage sensor, a recent study showed that PKA phosphorylation of a neuronal 2P channel, KCNK2, converts the channel from a constitutively open channel to an[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
15527815
reach
"In addition, phosphorylation of TREK-1 by protein kinase A or C can results in channel inactivation."
11165377
sparser
"In addition, phosphorylation of TREK-1 by protein kinase A or C can results in channel inactivation."
11165377
reach
"PKA directly phosphorylates TRPV1 and the heat sensitive potassium channel TREK, and in both cases, this phosphorylation modulates the electrophysiological properties of the channel."
15249591
reach
"In addition to its role in adipocyte differentiation, some reports indicate that PKA phosphorylates the COOH terminal region of the TREK subfamily and inhibits channel activity [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25501330