IndraLab

Statements

USP8 is ubiquitinated. 27 / 27
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"USP8 ubiquitination regulates the level of ASCL1."
37783914
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"In summary, USP8 ubiquitination regulates ASCL1 expression."
37783914
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"NRG1-mediated ubiquitination and degradation of USP8 can be abrogated by knockdown of Nrdp1 or USP8 in breast cancer cells [95] ."
36872193
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"These data suggest a reciprocal E3-DUB relationship in which GRAIL can ubiquitinate USP8, and ubiquitinated USP8 can de-ubiquitinate GRAIL."
21078124
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"Thus, our current working model is that Otub 1 promotes GRAIL degradation by de-ubiquitination of ubiquitinated USP8, thereby diminishing USP8 activity ( xref )."
21078124
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"USP8 ubiquitination regulates ASCL1 expression."
37783914
sparser
"This effect is co-activated by the deubiquitinases USP8 and USP9X. The AKT kinase has been previously shown to decrease USP8 function by increasing USP8 ubiquitination and decreasing active steady-state USP8 level [ xref ]."
27203743
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"Next to this, RNF41 regulates the intracellular trafficking of certain JAK2-associated cytokine receptors by ubiquitinating and suppressing USP8, which, in turn, destabilizes the ESCRT-0 complex."
29560723
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"Mechanistically, the E3 ligase Nrdp1 indirectly destabilizes the ESCRT-0 complex by ubiquitinating and suppressing USP8."
31845722
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"Among these, we identified 254 peptides that are ubiquitinated in USP8 down-regulating flies only ( xref ) and 347 that are only ubiquitinated in WT flies ( xref )."
37190052
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"The deubiquitinase USP8 stabilizes the E3 ligase RNF41, and RNF41 in turn ubiquitinates and destabilizes USP8 to regulate LepR degradation [ xref ]."
37724323
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"Previous studies have established that USP8 stabilizes RNF41 by removal of destabilizing ubiquitin linkages, while RNF41 reciprocally induces USP8 ubiquitination and its subsequent proteasomal degradation."
37547544
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"In the present study the linkage between PTEN loss, Akt activation, and USP8 levels and activity appeared to be somewhat different, and in our work Akt activation decreased, rather than enhanced, USP8 function by increasing USP8 ubiquitination and decreasing steady-state USP8 levels (data not shown)."
20484045
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"This increased ubiquitination was dependent on the E3 activity of GRAIL, as no enhanced ubiquitination of USP8 was observed in the presence of the H2N2 ligase defective mutant of GRAIL."
21078124
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"We imported these 12 proteins and USP8 in STRING database, and found that only NBR1 exists a potential interaction with USP8 (Fig. xref ) Ubiquitination motifs consisting of 20 residues surrounding the modified lysine site by Motif-x was showed in Fig. xref and the peak map of the possible ubiquitin sites of NBR1 (K767 and K887) identified by mass spectrometry analysis was presented in Fig. xref ."
40410130
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"It does so by ubiquitinating, destabilizing and relocalizing the deubiquitinase USP8 (ubiquitin-specific protease 8)."
28542518
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"In EGF-stimulated cells, UBPY underwent ubiquitination and bound to EGFR."
16120644
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"Next to ubiquitinating BRUCE, Parkin and USP8 [ xref , xref , xref ], it is known to downregulate ErbB3 and ErbB4 receptors, as well as several type I cytokine receptors such as the IL-3, EPO, IL-6, LIF and LR [ xref , xref – xref ]."
28542518
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"It reroutes IL6Rα, LIFRα and LR from the lysosomal degradation pathway to compartments where ectodomain shedding occurs by ubiquitinating and suppressing USP8 [ xref , xref ]."
28542518
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"Others suggest that USP8 counter-regulates EGF-induced ubiquitination of the ESCRT-III component CHMP1B, allowing it to assemble into a membrane-associated ESCRT-III polymer required for budding [ xref ]."
31845722
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"Otub1-ARF1 is a catalytically inactive form of Otub1 and competitively inhibits Otub1 by competing for binding to GRAIL and allowing ubiquitinated USP8 to bind to and deubiquitinate GRAIL, thus preserving GRAIL levels ( xref )."
40852720
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"In particular, IL-2R signaling leads to Akt and mTOR activation, Otub1 translation, de-ubiquitination of ubiquitinated USP8, and subsequent degradation of GRAIL that permits T cell proliferation."
21078124
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"In the subset that was found to be ubiquitinated only in USP8 down-regulating flies, gene ontology analysis identified enrichment in ubiquitinated proteins that belong to signaling pathways regulating tissue differentiation and development (Hedgehog, dorsoventral axis formation and FoxO signaling pathways) and components of the mitophagy pathways ( xref )."
37190052
sparser
"Furthermore, the presence of wild-type GRAIL along with USP8 increased the amount of ubiquitinated USP8, which was further enhanced when the DUB activity of USP8 was abolished."
21078124
sparser
"The RNF41 promotes USP8 ubiquitination and degradation whereas the USP8 promotes removing the ubiquitin from RNF41 and thus stabilize it."
33600786
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"In summary, this study indicates that USP8 ubiquitination regulates ASCL1 expression and mediates CD47 transcriptional activation of the AKT signaling pathway and that glycolysis promotes osteogenic differentiation of hBMSCs."
37783914
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"RNF41 redistributes and ubiquitylates USP8, and reduces USP8 levels."
23750007