IndraLab

Statements

USP8 is ubiquitinated. 15 / 15
| 15
sparser
"These data suggest a reciprocal E3-DUB relationship in which GRAIL can ubiquitinate USP8, and ubiquitinated USP8 can de-ubiquitinate GRAIL."
21078124
sparser
"In the present study the linkage between PTEN loss, Akt activation, and USP8 levels and activity appeared to be somewhat different, and in our work Akt activation decreased, rather than enhanced, USP8 function by increasing USP8 ubiquitination and decreasing steady-state USP8 levels (data not shown)."
20484045
sparser
"It does so by ubiquitinating, destabilizing and relocalizing the deubiquitinase USP8 (ubiquitin-specific protease 8)."
28542518
sparser
"In particular, IL-2R signaling leads to Akt and mTOR activation, Otub1 translation, de-ubiquitination of ubiquitinated USP8, and subsequent degradation of GRAIL that permits T cell proliferation."
21078124
sparser
"This effect is co-activated by the deubiquitinases USP8 and USP9X. The AKT kinase has been previously shown to decrease USP8 function by increasing USP8 ubiquitination and decreasing active steady-state USP8 level [ xref ]."
27203743
sparser
"This increased ubiquitination was dependent on the E3 activity of GRAIL, as no enhanced ubiquitination of USP8 was observed in the presence of the H2N2 ligase defective mutant of GRAIL."
21078124
sparser
"Next to ubiquitinating BRUCE, Parkin and USP8 [ xref , xref , xref ], it is known to downregulate ErbB3 and ErbB4 receptors, as well as several type I cytokine receptors such as the IL-3, EPO, IL-6, LIF and LR [ xref , xref – xref ]."
28542518
sparser
"Thus, our current working model is that Otub 1 promotes GRAIL degradation by de-ubiquitination of ubiquitinated USP8, thereby diminishing USP8 activity ( xref )."
21078124
sparser
"RNF41 redistributes and ubiquitylates USP8, and reduces USP8 levels."
23750007
sparser
"Others suggest that USP8 counter-regulates EGF-induced ubiquitination of the ESCRT-III component CHMP1B, allowing it to assemble into a membrane-associated ESCRT-III polymer required for budding [ xref ]."
31845722
sparser
"Furthermore, the presence of wild-type GRAIL along with USP8 increased the amount of ubiquitinated USP8, which was further enhanced when the DUB activity of USP8 was abolished."
21078124
sparser
"It reroutes IL6Rα, LIFRα and LR from the lysosomal degradation pathway to compartments where ectodomain shedding occurs by ubiquitinating and suppressing USP8 [ xref , xref ]."
28542518
sparser
"In EGF-stimulated cells, UBPY underwent ubiquitination and bound to EGFR."
16120644
sparser
"Next to this, RNF41 regulates the intracellular trafficking of certain JAK2-associated cytokine receptors by ubiquitinating and suppressing USP8, which, in turn, destabilizes the ESCRT-0 complex."
29560723
sparser
"Mechanistically, the E3 ligase Nrdp1 indirectly destabilizes the ESCRT-0 complex by ubiquitinating and suppressing USP8."
31845722