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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Ubiquitin inhibits EIF3F. 1 / 1

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"The reduced Akt1 kinase activity observed upon statins treatment, resulted in an increase in dephosphorylation on FoxO3 and FoxO1 transcription factors, their translocation into the nucleus, and activation of the Atrogin1 and MAFbx gene encoding ubiquitin ligase E3, which eliminates MyoD, calcineurin, eIF3-F translation initiator, and FoxO1 [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...