IndraLab

Statements

RAS activates USP22. 3 / 3
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"These findings suggest that SOS1/RAS and downstream ERK and PI3K/AKT pathways mediate the oncogenic role of USP22 in gastric cancer."
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"These results suggest that SOS1/RAS signaling mediates the oncogenic role of USP22 in gastric cancer."
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"Furthermore, our study indicated that SOS1 was upregulated in USP22-overexpressing gastric cancer cells and xenograft tumor tissue, accompanied by activation of the RAS/ERK and PI3K/AKT pathways, suggesting that SOS1/RAS signaling mediates the oncogenic role of USP22 in gastric cancer."
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