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USP2 activates glucose. 5 / 5
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"Consistently, we found that mice transduced with siUSP2 adenovirus have impaired ability to convert pyruvate into glucose during PTT (XREF_FIG), suggesting that hepatic gluconeogenesis and glucose output are impaired by RNAi knockdown of USP2 in the liver."
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"Several USPs, including USP2, USP10, USP14, USP15, USP18, and USP22, have been associated with obesity and related metabolic disorders.In diet-induced obese mice, it is reported that USP2 can increase the production of hepatic glucose and promote glucose intolerance (143)."
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"Nfil3 is a known negative regulator of gluconeogenesis (Kang et al. 2017), while Usp2 stimulates glucose production (Molusky et al. 2012)."
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"Correspondingly, infection with an adenovirus encoding Usp2 shRNA significantly lowered blood glucose, blood insulin, hepatic glycogen content, and insulin sensitivity in high fat diet–fed mice, suggesting that USP2 plays a role in aggravating T2DM pathogenesis [102]."
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"USP2 modulates glucose and lipid metabolism, insulin sensitivity, and inflammatory processes."
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