IndraLab

Statements

TRIM28 activates OTUD5. 3 / 3
| 3
reach
"Depletion of OTUD5 in TRF2ts MEFs with 2 independent sgRNAs (g1, g1B) recapitulated the pKAP1 defect observed with shRNA-mediated knockdown of OTUD5 (Fig. 1i, j)."
39420004
reach
"Moreover, ectopic expression of phosphomimic KAP1 also rescued the telomere MMEJ defect in OTUD5-depleted Trf1 ;Trf2 ;Ku70 ;p53 ;Cre-ER MEFs (Fig. 5g, Supplementary Fig. 7d, e)."
39420004
reach
"Indeed, overexpression of KAP1 restored telomere fusion efficiency in OTUD5-depleted cells, while ectopic expression of wild-type (KAP1 ) failed to do so (Fig. 5e, f, Supplementary Fig. 7b, c)."
39420004