IndraLab

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ATXN3 activates PTEN. 3 / 4
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"Therefore, ATXN3 may directly regulate the PTEN transcript, or indirectly affect it through regulation of a ceRNA such as PTENP1."
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"The results showed that Ataxin-3 promoted testicular cancer cell proliferation by inhibiting PTEN and indirectly activating the AKT/mTOR signaling pathway.From January 2012 to October 2017, 53 pairs o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, the two individual ATXN3 siRNAs (siATXN3_3 and _ 5) that caused the most profound PTEN induction (XREF_FIG and XREF_FIG) blunted Akt T308 phosphorylation in response to EGF (XREF_FIG)."
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