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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 activates PTEN. 2 / 3

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"In contrast, the two individual ATXN3 siRNAs (siATXN3_3 and _ 5) that caused the most profound PTEN induction (XREF_FIG and XREF_FIG) blunted Akt T308 phosphorylation in response to EGF (XREF_FIG)."

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"Therefore, ATXN3 may directly regulate the PTEN transcript, or indirectly affect it through regulation of a ceRNA such as PTENP1."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...