IndraLab

Statements

CCCP inhibits CASP1. 3 / 3
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"However, CCCP induced inhibition of caspase-1 activation by LPS and ATP was also evident in Atg5 -/- BMDMs (XREF_FIG)."
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"Addition of CCCP 15 min after infection blocked macrophage cell death, the activation of caspase-1 and the maturation of IL-1beta, without affecting uptake or escape of S. flexneri from the phagosome."
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"Consistently, CCCP abolished LPS and nigericin triggered caspase-1 activation in NLRP3-stably expressing macrophages (XREF_FIG), demonstrating that CCCP mediated inhibition of NLRP3 inflammasome is not resulted from the reduced NLRP3 expression."
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