IndraLab

Statements

UCHL1 inhibits AKT. 5 / 6
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"Taken together, it appears that UCHL1 suppresses the growth of LNCaP cells via stabilization of tumour suppressor protein such as p53 and by inactivating AKT and PKB pathway."
21999842
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"Taken together, it appears that UCHL1 suppresses the growth of LNCaP cells via stabilization of tumour suppressor protein such as p53 and by inactivating AKT and PKB pathway."
21999842
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"These data provide the first in vivo evidence for DUB driven oncogenesis and suggest that UCH-L1 hyperactivity deregulates normal Akt signaling."
20574456
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"The effect of UCHL1 overexpression on CSCs was suppressed by inhibiting the PI3K/AKT pathway which suggests a role of UCHL1 in liver fibrosis and cancer."
35924961
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"Our data suggest that PI3K and Akt pathway is possibly involved in apoptosis in breast cancer cells and blocked by UCH-L1."
18949367