IndraLab

Statements

USP8 inhibits FGFR2. 3 / 3
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"These results suggest that suppressing USP8 in ARID1A-deficient cell lines enhances the degradation of FGFR2 but not EGFR.In the initial screening in Fig. 1A, FGFR2 was not identified as a synthetic lethal target candidate."
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"This study shows that inhibition of USP8 specifically causes FGFR2 proteolysis through the proteasome system in ARID1A-deficient cells."
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"These data suggest that suppressing USP8 in ARID1A-deficient cell lines triggers the degradation of FGFR2, thereby inducing synthetic lethality.In ARID1A-deficient cells, USP8 expression tended to be low (Fig. 1D)."
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