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USP22 activates ERBB2. 4 / 4
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"USP22 promotes HER2 driven mammary carcinoma aggressiveness by suppressing the unfolded protein response."
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"The current work provides evidence that the USP22 deubiquitinase, part of the DUBm of the SAGA complex, supports the mitochondrial biogenesis transcriptomic program to foster the CSC traits and promote the drug resistant features of HER2 -BC and TNBC cells (Fig. 7)."
38347585
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"To determine whether Usp22 overexpression might enhance ERBB2-driven formation of mammary tumors, we introduced our previously described Lox-Stop-Lox (LSL) Usp22 allele [17] into mice carrying the MMTV-NIC transgene (Fig 1A)."
38236941
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"In conclusion, USP22 strongly supports the drug-tolerant behavior of HER2 -BC and TNBC and is a promising therapeutic target to improve standard as well as OXPHOS-based therapies (Fig. 7E)."
38347585