IndraLab

Statements

CYLD activates SMAD7. 3 / 3
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"The study performed in CYLD-knockout mice reported that CYLD targets SMAD7 protein for deubiquitylation and inhibits TGF-beta signalling in the development of regulatory T cells."
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"We then traced this finding to the fact that the absence of CYLD leads to excess ubiquitination and increased activity of Smad7, a TGF-beta-induced signaling molecule that controls TAK1 kinase activity."
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"The Deubiquitinase CYLD Targets Smad7 Protein to Regulate Transforming Growth Factor beta (TGF-beta) Signaling and the Development of Regulatory T Cells *."
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