IndraLab

Statements

SKA-31 activates KCNN1. 2 / 2
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reach
"While SKA-31 activated both KCa2.1 and KCa2.3 with an EC 50 of 2.9 muM, SKA-20 showed roughly 3-fold higher activity on KCa2.1 (EC 50 430 nM) than on KCa2.3 (EC 50 1.2 muM)."
18955585
reach
"Out of a library of 41 benzothiazoles we identified two compounds, SKA-20 (anthra [2,1-d] thiazol-2-ylamine) and SKA-31 (naphtho [1,2-d] thiazol-2-ylamine), which are 10-20 times more potent than riluzole and activate KCa2.1 with EC 50 s of 430 nM and 2.9 muM, KCa2.2 with EC 50 s of 1.9 muM, KCa2.3 with EC 50 s of 1.2 muM and 2.9 muM, and KCa3.1 with EC 50 s of 115 nM and 260 nM."
18955585