IndraLab

Statements

USP13 activates DDR. 4 / 4
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"In response to DNA damage, USP13 is phosphorylated by ATM, which in turn facilitates USP13 recruitment to DSBs, RAP80 deubiquitination, and triggers DDR signalling."
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"Therefore, we hypothesized that USP13/PARP1 may enhance MM cell proliferation by mediating DDR."
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"These findings demonstrate that BA can retard the development of MM by targeting USP13/PARP1‐mediated DDR and triggering cell apoptosis, providing a novel mechanism of action for BA in MM (Figure 7H).4 Discussion."
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"These findings confirm that the USP13/PARP1 axis positively regulates the DDR of MM cells, promoting MM cell proliferation.3.6 BA Inhibits MM Cell Proliferation in Vitro by Targeting the USP13/PARP1 Axis."
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