IndraLab

Statements

USP22 inhibits EGFR. 3 / 3
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"We show here that overexpression of USP22 prevents EGFR down-regulation, while shRNA mediated silencing of USP22 enhances EGFR degradation."
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"Our current study demonstrates that USP22 promotes EGFR-TKIs resistance by preventing EGFR degradation in EGFR-mutant lung ADC."
29981430
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"Cancer cells express proteins such as sortilin, tribbles homolog 3 protein (TRIB3), and ubiquitin specific peptidase 22 (USP22), which suppress EGFR degradation via EGFR stabilization, and their knockdown inhibits cancer cells [39–41]."
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