IndraLab

Statements

USP22 inhibits EGFR. 3 / 3

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"We show here that overexpression of USP22 prevents EGFR down-regulation, while shRNA mediated silencing of USP22 enhances EGFR degradation."

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"Our current study demonstrates that USP22 promotes EGFR-TKIs resistance by preventing EGFR degradation in EGFR-mutant lung ADC."

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"USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination mediated EGFR degradation in EGFR-mutant lung adenocarcinoma."

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INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP22 inhibits EGFR. 3 / 3

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