IndraLab

Statements



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"Functional assays demonstrated that overexpression of USP28 promoted cell proliferation and aerobic glycolysis of colorectal cancer, while USP28 inhibition could reverse these effects."

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"USP28 increases aerobic glycolysis and promotes cell proliferation upon stabilization of FOXC1 [50]."
| PMC

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"Further, lack of USP28 promotes a more malignant state of breast cancer cells, indicated by an epithelial-to-mesenchymal (EMT) transition, elevated proliferation, migration, and angiogenesis as well as a decreased adhesion."

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"Down-regulation of USP28 promoted NSCLC cells proliferation and induced cells apoptosis."

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"Previous reports showed that 53BP1 and USP28 activate p53, preventing the proliferation of cells that have an increased chance of mitotic errors [104]."
| PMC

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"Moreover, the upregulation of CCND1 and USP28 partially reverses the impaired proliferation and promoted apoptosis rate induced by miR-3940-5p in A549 cells (XREF_FIG, E-H)."

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"XREF_BIBR reported that overexpression of USP28 promotes NSCLC cell proliferation and apoptosis inhibition and is associated with poor prognosis in NSCLC patients."

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"We found that up-regulation of USP28 in NSCLC cell lines promoted cells proliferation."

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"USP28 contributes to the proliferation and metastasis of gastric cancer."

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"USP28 increases aerobic glycolysis and promotes cell proliferation upon stabilization of FOXC1 [ 50 ] ."
| PMC

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"MiR-500a-5p was transferred from CAFs to the cancer cells, and subsequently promoted proliferation and metastasis by binding to ubiquitin specific peptidase 28 (USP28)."

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"Recently, upregulation of USP28 has been reported to be associated with poor prognosis in NSCLC patients and promote NSCLC cell proliferation XREF_BIBR."

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"This suggests that Usp28 in different cellular contexts is a mediator of proliferation."

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"Overexpressing USP28 was found in NSCLC tumors and enhanced NSCLC cell proliferation, and low survival was related to high USP28 levels in patients."

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"Overexpression of USP28 promoted NSCLC cells proliferation, and was associated with poor prognosis in NSCLC patients."

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"In conclusion, our data indicated that high expression of USP28 in NSCLC promoted tumour cells proliferation, and miR-4295 may target USP28."

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"The exact mechanism by which USP28 promotes NSCLC cell proliferation is undetermined yet."

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"Loss of 53BP1, USP28, or TRIM37 suppresses p53 elevation and proliferation arrest triggered by centrosome loss."

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"Up-regulation of USP28 promoted NSCLC cells proliferation."

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"Collectively, our data suggested that high levels of miR-500a-5p in CAFs are transferred into tumor cells and downregulates USP28 expression, which promotes cell proliferation, metastasis and EMT in breast cancer."

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"The cancer promoting role of USP28 was confirmed by in vitro assays where overexpressing USP28 could enhance NSCLC cell proliferation while downregulating it induced apoptosis."

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"Ectopic USP28 expression promoted proliferation of SW1783 glioma cells both in vitro and in vivo, and conferred enhanced tumorigenicity in a nude mouse model."

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"Besides, we proved that in A549 and H1299, up-regulation of USP28 promoted NSCLC cells proliferation."

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"Given the current inability to use drugs to directly target USP28 driven cancer proliferation, our study suggests a novel alternative approach of targeting USP28 stability by development of HDAC5 specific inhibitors in cancer."