IndraLab

Statements

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"Further, lack of USP28 promotes a more malignant state of breast cancer cells, indicated by an epithelial-to-mesenchymal (EMT) transition, elevated proliferation, migration, and angiogenesis as well as a decreased adhesion."
29545478
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"Recently, upregulation of USP28 has been reported to be associated with poor prognosis in NSCLC patients and promote NSCLC cell proliferation XREF_BIBR."
27988424
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"Although the functions of ΔNp63 are independent of p53, these results indicate that USP28 promotes the cell cycle through its impacts on ΔNp63 and then accelerates cell proliferation."
36879346
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"Therefore, mediated by LSD1, USP28 can accelerate the cell cycle and promote cell proliferation."
36879346
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"USP28 increases aerobic glycolysis and promotes cell proliferation upon stabilization of FOXC1 [50]."
| PMC
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"Overexpression of USP28 promoted NSCLC cells proliferation, and was associated with poor prognosis in NSCLC patients."
25656529
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"Up-regulation of USP28 promoted NSCLC cells proliferation."
25656529
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"We found that up-regulation of USP28 in NSCLC cell lines promoted cells proliferation."
25656529
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"This suggests that Usp28 in different cellular contexts is a mediator of proliferation."
20543859
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"MiR-500a-5p was transferred from CAFs to the cancer cells, and subsequently promoted proliferation and metastasis by binding to ubiquitin specific peptidase 28 (USP28)."
33664871
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"Down-regulation of USP28 promoted NSCLC cells proliferation and induced cells apoptosis."
25656529
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"Previous reports showed that 53BP1 and USP28 activate p53, preventing the proliferation of cells that have an increased chance of mitotic errors [104]."
| PMC
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"In addition to promoting the cell cycle and enhancing aerobic glycolysis, USP28 can also stimulate cell proliferation."
36879346
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"Moreover, the upregulation of CCND1 and USP28 partially reverses the impaired proliferation and promoted apoptosis rate induced by miR-3940-5p in A549 cells (XREF_FIG, E-H)."
27988424
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"Besides, we proved that in A549 and H1299, up-regulation of USP28 promoted NSCLC cells proliferation."
25656529
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"In conclusion, our data indicated that high expression of USP28 in NSCLC promoted tumour cells proliferation, and miR-4295 may target USP28."
25656529
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"XREF_BIBR reported that overexpression of USP28 promotes NSCLC cell proliferation and apoptosis inhibition and is associated with poor prognosis in NSCLC patients."
27988424
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"USP28 contributes to the proliferation and metastasis of gastric cancer."
30485491
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"Further, the high expression of the deubiquitinating enzyme USP28 was targeted by miR-4295, promoting non-small cell lung cancer cell proliferation [45]."
37450415
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"Through the miR‐500a‐5p/ubiquitin specific peptidase 28 (USP28) axis, exosomal miR‐500a‐5p in CAFs could promote cancer cell proliferation, EMT, and metastasis [57]."
40032646
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"Finally, the functional experiments confirmed that USP28 significantly promoted proliferation, invasion, and migration, which agrees with previous tumor studies [11, 67, 68]."
37450415
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"The experiments in vitro confirmed that USP28 could promote cell proliferation, migration, and invasion in the HCC cell lines."
37450415
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"Given the current inability to use drugs to directly target USP28 driven cancer proliferation, our study suggests a novel alternative approach of targeting USP28 stability by development of HDAC5 specific inhibitors in cancer."
27212032
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"Knockdown of either Usp28 or Usp36 downregulates Myc and suppresses cancer cell proliferation in cell culture."
26459133
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"Functional assays demonstrated that overexpression of USP28 promoted cell proliferation and aerobic glycolysis of colorectal cancer, while USP28 inhibition could reverse these effects."
34106567
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"USP28 overexpression induces cancer cell proliferation [177]."
35884607
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"Ectopic USP28 expression promoted proliferation of SW1783 glioma cells both in vitro and in vivo, and conferred enhanced tumorigenicity in a nude mouse model."
29415985
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"Collectively, our data suggested that high levels of miR-500a-5p in CAFs are transferred into tumor cells and downregulates USP28 expression, which promotes cell proliferation, metastasis and EMT in breast cancer."
33664871
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"Overexpressing USP28 was found in NSCLC tumors and enhanced NSCLC cell proliferation, and low survival was related to high USP28 levels in patients."
33572615
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"USP28 increases aerobic glycolysis and promotes cell proliferation upon stabilization of FOXC1 [ 50 ] ."
| PMC
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"Conversely, one study showed that loss of USP28 reduces checkpoint activation, thus facilitating cell proliferation[32]."
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"For example, USP2, USP22, USP28, and USP37 stabilize c-Myc expression and, thus, stimulate the proliferation of many tumour cells [58–61] ."
34678225
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"Further, indirect downregulation of MYC via ubiquitin–proteasome mechanisms is an excellent strategy for targeting CSCs, for instance activating SCF [54] and inhibiting deubiquitinase USP28 of MYC suppresses cell proliferation in diverse cancer [55]."
36765885
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"The deubiquitinase USP28 promotes malignant features such as G2 arrest in response to genotoxic stress and proliferation [37]."
38076191
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"USP28 increases the stabilization of c-MYC and cyclin E1, thereby promoting the proliferation of cancer cells [39]."
38076191
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"After stabilizing FOXC1, USP28 enhances aerobic glycolysis and promotes cell proliferation."
39222275
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"The cancer promoting role of USP28 was confirmed by in vitro assays where overexpressing USP28 could enhance NSCLC cell proliferation while downregulating it induced apoptosis."
29415985
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"Moreover, FACS analysis indicated that downregulation of USP28 expression by siRNA decreased the PASMCs proliferation rate ( Fig. 4 D)."
30149918
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"USP28 has been reported to promote the proliferation of both tumor and normal cells by stabilizing Claspin [41]."
38076191
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"Follow up on our initial observations that knocking down USP28 increased cell proliferation, the function of USP28 in regulation of cell proliferation was assayed by the colony formation assay using U[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30910399
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"Loss of 53BP1, USP28, or TRIM37 suppresses p53 elevation and proliferation arrest triggered by centrosome loss."
27432897
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"Furthermore, two deubiquitinating enzymes, USP9X and USP28, have significant expression in HCC and could similarly promote HCC cell proliferation by regulating the activity of this pathway (128, 129)."
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"Usp28 cooperates with Fbw7 to induce cell proliferation in cancers."
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