IndraLab

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OTUB2 activates GINS1. 2 / 2
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"Further investigations revealed that OTUB2 mediated the malignant progression of colon cancer by regulating GINS1."
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"Therefore, we also intended to investigate whether OTUB2 enhances the stem cell properties of colon cancer cells by modulating GINS1, thereby promoting chemotherapy resistance and EMT.SP1 can be categorized into four domains based on their respective functions: the dsDNA binding domain, the SP1 transcriptional activity domain, the Btd domain, and the SP domain [23]."
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