IndraLab

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Genistein inhibits NLRP3. 10 / 10
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"Genistein inhibits Nlrp3/caspase-1 signalling to alleviate traumatic brain injury-induced anxiety-like behaviours in rats."
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"To investigate the underlying mechanism, we also examined whether Genistein could suppress the activation of NLRP3 in vitro."
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"These results clearly demonstrated that cAMP is the direct mechanism of Genistein-induced NLRP3 inhibition."
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"It has been shown that genistein can inhibit the NLRP3 inflammasome via TGR5-cAMP signaling in human macrophages (105).6.1.9 Alpinetin."
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"A study with dextran sulphate sodium (DSS)-induced murine colitis by targeting the inflammasome NLRP3, demonstrated that genistein inhibited NLRP3 inflammasome through macrophage TGR5-cAMP signaling, demonstrating that this could be a potentially effective drug for IBDs."
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"Genistein successfully suppressed the production of IL-1β, caspase-1 and the protein level of NLRP3 in colon, suggesting that down-regulation of NLRP3 inflammasome activation contributed to the benefi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Using the same cell line, namely HUVECs, Guihua et al. demonstrated that genistein reduced cell senescence in the HUVEC model by suppressing the TXNIP/NLRP3 axis."
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"Collectively, these results determined that Genistein inhibited the activation of NLRP3 inflammasome through disrupting the interaction between NLRP3 and ASC, leading to NLRP3-mediated ASC nucleation.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Genistein also inhibited Nlrp3/caspase-1 signalling, unveiling the effects of genistein in altering molecular pathways in brains with TBI."
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"Taken together, these findings suggested that Genistein markedly suppressed the activation of NLRP3 inflammasome in DSS-induced mice.In vivo, Genistein inhibited activation of NLRP3 inflammasome and d[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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