IndraLab

Statements

UFL1 binds BAP1. 5 / 5
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"Additionally, the structural characterization of the UFL1-BAP1 complex will be instrumental in guiding such efforts and may uncover specific binding pockets or allosteric sites that could be targeted to modulate this interaction with higher specificity."
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"Considering the frequent mutations and deletions of the TP53 gene in human cancers, the stabilization of pVHL by the UFL1-BAP1 axis might be particularly important in cancer cells harboring TP53 mutant or loss, such as CRC cells (SW620 and HCT116 with p53 KO) and pancreatic cancer cells (AsPC-1) (fig."
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"However, several features of the BAP1-UFL1 interaction identified in our study offer pathways to address specificity."
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"Second, a more selective strategy may involve enhancing the specific interaction between UFL1 and BAP1."
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"For instance, high-throughput screening of Food and Drug Administration–approved drugs or other chemical libraries could identify small molecules that promote the UFL1-BAP1 interaction, thereby selectively enhancing BAP1 UFMylation."
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