IndraLab

Statements

reach
"We found that aspirin treatment induced degradation of IkappaBalpha in a similar concentration dependent manner in each cell line genotype (XREF_FIG)."
15770215
sparser
"Thus inhibition of NFKBIA by Acetylsalicylic acid could increase NF-kB activity and confer an antiapoptotic state for the irradiated cells."
33692493
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"Our previous work demonstrated that aspirin induces time- and dose dependent signal specific degradation of IkappaBalpha, nuclear translocation of NFkappaB and apoptosis in CRC cells."
15188000
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"Furthermore, inhibition of c-Src activity, by chemical inhibition or expression of a kinase dead form of the protein abrogates aspirin mediated degradation of IkappaBalpha, nuclear translocation of RelA and apoptosis, suggesting a causal link."
21551129
reach
"Thus inhibition of NFKBIA by Acetylsalicylic acid could increase NF-kB activity and confer an antiapoptotic state for the irradiated cells."
33692493
reach
"We also demonstrated that aspirin induced IkappaBalpha degradation was required for apoptosis because cells constitutively expressing super-repressor IkappaBalpha were resistant to both aspirin induced NFkappaB nuclear translocation and apoptosis."
15770215