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TP53 bound to EP300 activates TP53. 2 / 2
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"N-terminal phosphorylation enhances subsequent p53 interaction with the acetyltransferases p300/CBP and PCAF, which in turn promote acetylation of C-terminal lysines and activate sequence-specific DNA[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In contrast, the absence of CSB would increase the binding of p53 to p300 causing the stabilization of p53 and the activation of its target genes including the ones involved in the apoptotic commitment."
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