IndraLab

Statements

USP6 binds CDH11. 16 / 16
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"It is verified that the CDH11-USP6 fusion transcript is a specific transcript of ABC, the oncogenic property of which is closely linked with the upregulated transcription of USP6 [ 185 ]."
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"Targeted RNA sequencing was performed and showed an USP6::CDH11 gene fusion, which is a highly specific and diagnostic gene fusion for ABC ( xref ) [ xref , xref ]."
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"The result of the CDH11–USP6 chimeric gene is that USP6 is transcriptionally upregulated."
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"We observed 25 gene fusions, namely 9 SS18::SSX1 , 8 EWSR1::FLI1 , 3 PAX3::FOXO1 , 2 EWSR1::WT1 , 1 EWSR1::NR4A3 , 1 HEY1::NCOA2 , and 1 CDH11::USP6 ( xref )."
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"CDH11-USP6 fusion is one of the most frequently identified genetic abnormalities (30% of cases) and additional mutations continue to be described [ xref ]."
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"CDH11-USP6 translocation is the most common, found in approximately one third of ABCs, while the frequency of other fusion partners is not known, due to the large number of fusion partners and small n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"PCR primers for RT-PCR evaluation of the CDH11-USP6 fusion oncogene were CDH11 +71F (5′-CGCCGCTGACTTGTGAAT-3′) and USP6 +1781R (5′-CTCGGTGTCCCTTGTCATACTT-3′)."
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"USP6 rearrangements exist in 65 to 70% of ABC cases and CDH11-USP6 fusion is present in an additional 30% of cases [ xref ]."
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"Of these, 10 cases (28%) exhibited rearrangement of both loci, and a fusion transcript CDH11-USP6 was confirmed by RT-PCR in each of these cases."
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"Furthermore, RT-PCR reactions corroborated these molecular cytogenetic results showing the presence of CDH11-USP6 fusion transcripts in these tumors."
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"Another author has looked specifically at cases with the t(16;17)(q22;p13) translocation and has characterized the fusion product of this event as CDH11-USP6 ."
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"CDH11-USP6 RT-PCR validations were performed in a representative group of the ABC with FISH rearrangements of USP6 only, CDH11 only, or neither USP6 or CDH11 , and each of these tumors lacked the CDH1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A USP6 rearrangement is present in approximately 65% to 70% of ABC cases, with CDH11-USP6 fusion in 30%."
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"In these lesions, both the primary tumor component as well as the secondary ABC lacked CDH11 and USP6 rearrangements by FISH ( Figure 1, D and E ), and lacked CDH11-USP6 fusion transcripts by RT-PCR."
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"In a recent study, ubiquitin-specific protease 6 (USP6) gene rearrangement was found to be associated with 65–70% of cases, whereas CDH11-USP6 fusion was associated with 30% of cases [ xref ]."
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"The CDH11-USP6 translocation was found in 5 of 13 (38%) cases, while 7 novel fusion partners were identified in the other 8 cases, CTNNB1, E1F1, FOSL2, PAFAH1B1, RUNX2, SEC31A and STAT3, some of them [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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