IndraLab

Statements

USP4 binds RIPK1. 5 / 9
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"Taken together, these data indicate RIP1 and USP4 form a complex through the USP domain of USP4.To test the role of USP4 in RIP1 ubiquitination, RIP1 was co-expressed with HA-ubiquitin and USP4 expres[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"An association between USP4 and RIP1 was reported to impair NF-kappaB activation and exacerbate TNF-alpha-induced apoptosis in head and neck squamous cell carcinoma (HNSCC)."
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"Co-immunoprecipitation showed that USP4 interacted with receptor-interacting protein 1 (RIPI) to remove K63-connected ubiquitin molecules to stabilize RIPI expression."
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"Furthermore, TNFalpha induced recruitment of USP4, TAK1 and RIPK1 to TNFR1 (XREF_FIG)."
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"Coimmunoprecipitation experiments showed that RIP1 interacted with USP4 WT and C261, but not with N260, indicating the C-terminal USP domain is required for the interaction with RIP1 ( Fig. 3 F)."
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