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"The diminished stimulation by ISO in the presence of PP2 on I HCN4, sinus node I f, action potentials, and spontaneous beating rate, respectively, supported the hypothesis that ISO can increase the sinus node pacemaker activity via a cAMP independent, Src mediated stimulation of HCN4 activity by phosphorylation on tentative tyrosine residues in the C-linker of the channel protein."