IndraLab

Statements

SRC activates HCN4. 5 / 6
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signor
"These results demonstrate that src tyrosine kinase enhances hcn4 currents by shifting their activation to more positive potentials and increasing the whole cell channel conductance as well as speeding the channel kinetics. The tyrosine residue that mediates most of src s actions on hcn4 channels is tyr531."
17977941
reach
"The diminished stimulation by ISO in the presence of PP2 on I HCN4, sinus node I f, action potentials, and spontaneous beating rate, respectively, supported the hypothesis that ISO can increase the sinus node pacemaker activity via a cAMP independent, Src mediated stimulation of HCN4 activity by phosphorylation on tentative tyrosine residues in the C-linker of the channel protein."
24566462
reach
"Alternative possibilities include indirect effects of RTK inhibition such as potential inhibition of Src kinase activity by crizotinib, as Src tyrosine kinase can enhance HCN4 channel activity by directly phosphorylating the channel protein [15, 29]."
28217366
reach
"Src kinase phosphorylation accelerates activation of HCN2 and HCN4, whereas there are conflicting data if it also leads to a shift in the HCN4 activation curve [XREF_BIBR, XREF_BIBR]."
25580535
reach
"These results demonstrate that Src tyrosine kinase enhances HCN4 currents by shifting their activation to more positive potentials and increasing the whole cell channel conductance as well as speeding the channel kinetics."
17977941