IndraLab

Statements


SRC activates HCN4. 4 / 6
1 | 4

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"Alternative possibilities include indirect effects of RTK inhibition such as potential inhibition of Src kinase activity by crizotinib, as Src tyrosine kinase can enhance HCN4 channel activity by directly phosphorylating the channel protein [15, 29]."

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"These results demonstrate that Src tyrosine kinase enhances HCN4 currents by shifting their activation to more positive potentials and increasing the whole cell channel conductance as well as speeding the channel kinetics."

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"Src kinase phosphorylation accelerates activation of HCN2 and HCN4, whereas there are conflicting data if it also leads to a shift in the HCN4 activation curve [XREF_BIBR, XREF_BIBR]."

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"The diminished stimulation by ISO in the presence of PP2 on I HCN4, sinus node I f, action potentials, and spontaneous beating rate, respectively, supported the hypothesis that ISO can increase the sinus node pacemaker activity via a cAMP independent, Src mediated stimulation of HCN4 activity by phosphorylation on tentative tyrosine residues in the C-linker of the channel protein."