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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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IFNL4 decreases the amount of USP18. 3 / 3

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"In conclusion, these data indicate that IFN-lambda4 attenuates the response of HCV genotype 1b to IFN-alpha therapy and inhibits the JAK-STAT signalling pathway by inducing USP18 expression."

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"These results demonstrate that virus induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18."

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"Recently, Fan et al. also demonstrated that IFN-lambda4 inhibits the JAK-STAT signalling pathway by inducing USP18 expression 28."

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IFNL4 decreases the amount of USP18. 3 / 3

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