IndraLab

Statements

IFNL4 decreases the amount of USP18. 3 / 3
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"In conclusion, these data indicate that IFN-lambda4 attenuates the response of HCV genotype 1b to IFN-alpha therapy and inhibits the JAK-STAT signalling pathway by inducing USP18 expression."
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"These results demonstrate that virus induced IFN-lambda4 potently blocks IFN-alpha signalling by inducing high protein levels of ISG15 and USP18."
28630501
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"Recently, Fan et al. also demonstrated that IFN-lambda4 inhibits the JAK-STAT signalling pathway by inducing USP18 expression 28."
28630501