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"It was also demonstrated that pioglitazone decreased oxidative stress, nuclear factor-kB (NFkB) activation and inflammation both in the spinal cord and skeletal muscle of SBMA mice [ 76 ]."

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"Wan et al. have shown that the PPAR gamma activator pioglitazone could attenuate caerulein induced p50 and p65 NF and kappaB dimer activity in the nucleus of caerulein treated AR42J cells [84]."