IndraLab

Statements

USP4 leads to the phosphorylation of SMAD2. 4 / 4
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"Further studies demonstrated that USP4 mediated TGF-beta1 activation not only enhances the phosphorylation of Smad2 through TGF-beta, but also directly upregulate matrix metalloproteinase (MMP)-9-mediated cell migration and invasion of breast cancer cells."
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"Furthermore, USP4 promotes the phosphorylation of SMAD2, thereby activating the TGF-β signaling pathway by upregulating Relaxin [62]."
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"USP4 directly deubiquitylates TGF-β receptor I to induce the phosphorylation of Smad2 and up-regulate matrix metalloproteinase (MMP)-9, thereby facilitating cell migration and invasion of breast cancer cells [28,29]."
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"Furthermore, USP4 promotes the phosphorylation of SMAD2, thereby activating the TGF-β signaling pathway by upregulating Relaxin [ xref ]."
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