IndraLab

Statements

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"Conversely, in many countries where couples pay for infertility treatments entirely, or are largely out-of-pocket, IVF is offered as the first-line treatment despite its invasive nature, lower cost-effectiveness, and associated safety concerns.The adoption of a prognosis-based approach confers several advantages, such as increased cost-effectiveness, improved safety, and reduced invasiveness or medicalization."
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"We report here that DHA inhibited NaV1.5 current and NHE-1 activity in human breast cancer cells, and in turn reduced NaV1.5-dependent cancer cell invasiveness."
25017107
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"Additionally, Nav 1.5 may inhibit proliferation, migration, and invasion through the Wnt/β-catenin signaling pathway by regulating cyclin D1 and c-Myc [38] ."
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"The fact that neither pharmacologic nor genetic knockdown of SCN5A inhibited cell invasion completely may be explained by the presence of other mechanisms that contribute to cell invasion, existence of additional functional isoforms (such as Na v 1.8, encoded by SCN10A , the most TTX-resistant isoform; see xref ), or simply incomplete gene knockdown."
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"In orthotopic breast cancer, downregulation of Nav1.5 significantly inhibited tumour growth, local invasion of surrounding tissues, and metastasis to the liver, lung, and spleen but had no significant effect on tumour cell proliferation and angiogenesis."
37033662
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"In a landmark study, stable down-regulation of Nav1.5 was shown to reduce tumor growth, lung colonization, local invasion, and MMP-9 immunopositivity in the orthotopic BCa mice model [ 62 ]."
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"Metastatic breast and colon cancer cells also express NaV1.5, predominantly the neonatal splice variant (nNaV1.5) and their inhibition by LAs reduces invasion and migration."
29958221
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"DHA inhibits NaV1.5 current and NHE1 activity in human breast cancer cells, and in turn reduces NaV1.5-dependent cancer cell invasiveness [262] ."
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"In the present study, we found specific blockage of Nav1.5 could inhibit cancer growth and invasive capacity, suggesting a tumor-promoting role and therapeutic implication of Nav1.5 in ovarian cancer.We found that blocking Nav1.5 by E3Ab inhibited migration and invasion properties of cancer cells, accompanied by decreased MMP-9 protein levels."
35116732
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"Downregulation of Nav1.5 expression in an orthotopic breast cancer model significantly reduced tumour growth, local invasion of surrounding tissues, and metastasis of the liver, lung, and spleen."
37033662
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"DHA inhibits Nav1.5 current and NHE-1 activity in human breast cancer cells, reducing the invasiveness of Nav1.5-dependent cancer cells (Wannous et al., 2015)."
37033662