IndraLab

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Pyruvic acid inhibits NFKB1. 4 / 4
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"At the in vitro level, ethyl pyruvate was found to inhibit nuclear factor kappa B (NFkB) activation in both cultured microglia and RAW 264.7 cells through a modification of its p65 subunit."
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"A higher concentration of ethyl pyruvate was necessary to inhibit the binding of p50 than that of RelA (1-220), which was consistent with the results of BN PAGE."
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"Next, we examined whether ethyl pyruvate inhibited the binding of RelA (1-220) or p50 to the [32 P]-labeled NF-kappaB probe."
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"Pyruvate treatment significantly decreased overall NFkB staining, as well as numbers of cells with nuclear staining."
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