IndraLab

Statements

UCHL3 binds EP300. 7 / 7
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"In response to activated TGF-β1 signaling, UCHL3 binds to p300 and deubiquitinates it in lung epithelial cells of IPF patients."
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"However, co-IP analysis showed that p300 could bind to UCHL3 but not UCHL5 or USP14, indicating that UCHL3 specifically binds to and stabilizes p300 in the context of TGF-β signaling (Fig. 3b)."
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"Mapping analysis showed that UCHL3 directly interacted with the bromodomain of p300 (Supplementary Fig. 12b–d)."
37524875
reach
"The interaction between UCHL3 and p300 was significantly increased by TGF treatment (Fig. 3c)."
37524875
sparser
"However, co-IP analysis showed that p300 could bind to UCHL3 but not UCHL5 or USP14, indicating that UCHL3 specifically binds to and stabilizes p300 in the context of TGF-β 1 signaling (Fig. xref )."
37524875
sparser
"Mapping analysis showed that UCHL3 directly interacted with the bromodomain of p300 (Supplementary Fig. xref )."
37524875
sparser
"The interaction between UCHL3 and p300 was significantly increased by TGF treatment (Fig. xref )."
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