IndraLab

Statements

USP3 binds SUZ12. 11 / 11
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"Therefore, this USP3-SUZ12 axis may contribute to tumor progression, thereby presenting a potential target for therapeutic intervention in human GC ( xref )."
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"To further confirm that USP3 was associated with the SUZ12 protein, we performed reciprocal co-immunoprecipitation experiments using endogenous protein and showed that USP3 can interact with SUZ12 (Fig. xref )."
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"Thus, targeting the USP3-SUZ12 axis may provide a potential therapeutic target for the treatment of GC."
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"The USP3-SUZ12 axis might promote tumor progression and could be a potential therapeutic candidate for human GC."
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"Collectively, these findings suggest that USP3 can physically interact with SUZ12."
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"Taken together, these data suggest that the USP3-SUZ12 axis promotes an EMT-like phenotype in GC cells."
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"We observed that USP3 interacted with and stabilized SUZ12 via deubiquitination."
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biogrid
No evidence text available
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biogrid
No evidence text available
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"These findings demonstrate that USP3 is an essential regulator of SUZ12 and that the USP3-SUZ12 signaling axis plays a critical role in the progression and metastasis of GC."
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"Moreover, USP3 interacts with SUZ12 in gastric cancer and regulates the homeostasis of SUZ12 through deubiquitylation, thereby promoting the migration and invasion of gastric cancer cells [ xref ]."
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