IndraLab

Statements


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"These results revealed a substantial co-localization of BAP1 and MLL4 on promoters and active enhancers.We next examined the recruitment of BAP1 and MLL4, as well as the distribution of H3K4me1 and H3K27ac, on BAP1 MLL4 promoters and active enhancers (Fig. 7c and Suppl."

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"To assess whether ASXLs play a role in regulating MLL4 and BAP1 binding at specific chromatin sites, we generated MLL4-, ASXL2-or BAP1-deficient human colon cancer HCT116 cells using the CRISPR/Cas9 approach."

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"Interdependent genomic binding of MLL4 and BAP1 on enhancers."