IndraLab
Statements
Nickel(2+) decreases the amount of USP28. 4 / 4
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"Although further studies did not show that hypoxia signaling impaired the association of USP28 with Fbw7alpha and c-Myc, cellular USP28 protein levels were decreased by Ni ions and hypoxia in A549 cells."
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"However, USP28 protein expression was decreased by Ni ions and hypoxia in the A549 cells (XREF_FIG)."
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"Our study demonstrated that Nickel and hypoxia exposure increased c-myc T58 phosphorylation and decreased USP28 protein levels in cancer cells, which both lead to enhanced c-myc ubiquitination and proteasomal degradation."
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"Here, it has been demonstrated that Ni ions and hypoxia increased H3K9m2 levels at the USP28 promoter and repressed USP28 gene expression."