IndraLab

Statements

Auranofin inhibits UCHL5. 4 / 4
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"Auranofin (Aur) inhibits proteasome associated deubiquitinases (DUBs) UCHL5 and USP14 rather than the 20S proteasome; inhibition of the proteasome associated DUBs is required for Aur induced cytotoxicity; and Aur selectively inhibits tumor growth in vivo and induces cytotoxicity in cancer cells from patients with acute myeloid leukemia [XREF_BIBR]."
25972356
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"The computational model also indicates that an active metabolite of auranofin can inhibit UCHL5 and USP14."
26097878
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"Auranofin was recently reported to inhibit proteasome activity at the level of the proteasome associated deubiquitinases (DUBs) UCHL5 and USP14."
30946948
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"HA-UbVS pretreatment of auranofin could bind the HA tagged UbVS in the purified 26S proteasome, supporting that auranofin inhibits UCHL5 and USP14."
26097878