IndraLab

Statements

EV71 decreases the amount of USP4. 3 / 3
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"From this study it can be speculated that EV71 infection inhibits USP4 expression and promotes TRAF6 polyubiquitination of K48-linkage as a way to regulate the proteasomal degradation of TRAF6."
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"These results suggest that EV71 infection inhibit the expression of USP4 in vitro and in vivo."
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"However, we found that EV71 infection inhibit the expression of USP4 to attenuate the activation of the NF-kappaB pathway, an example of an evolved mechanism through which EV71 antagonizes host defences."
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