IndraLab

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Ritonavir inhibits KCNH2. 2 / 2

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"Drug induced QT prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channels, and we showed that lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent block of HERG channels heterologously expressed in HEK293 cells in vitro."

15721475

➶

reach

"In vitro, lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent hERG channel blockade."

33345848

INDRA sources:

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IndraLab

Statements

Ritonavir inhibits KCNH2. 2 / 2

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