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USP12 leads to the phosphorylation of RELA. 2 / 2

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"After STING activation, TBK1 is recruited and activated to induce the activation of downstream IRF3 and NF-κB. Further evaluations showed that USP12 deficiency decreased the phosphorylation of p65 and IRF3 induced by HSV-1 (S7A Fig) but not by VSV (S7B Fig)."

37410794

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"By contrast, IFI6 overexpression in Usp12 BMDMs promoted the expression of IFN-β and IL-6 (Fig 7C) and phosphorylation of IRF3 and p65 (Fig 7D)."

37410794

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IndraLab

Statements

USP12 leads to the phosphorylation of RELA. 2 / 2

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