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SPATA2 activates CYLD. 14 / 18
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"TNF signaling enriched pathway identified in the present study, mediates SPATA2 gene-induced cell death by recruiting CYLD to the TNFR1 signaling complex (Masola et al. 2022)."
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"SPATA2 Activates CYLD."
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"SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling."
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"However, because there were too few NSCLC patients with distance metastasis (n = 3) (Table S1) in our group of specimens, no significance was obtained between the correlation of SPATA2 and M classification.Previously, SPATA2 was proved to bind to CYLD and enhance the activity of CYLD."
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"SPATA2 Activates CYLD."
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"To directly address if SPATA2 mediates the ability of CYLD to regulate baseline NF-kappaB activity, we ectopically expressed CYLD in WT, CYLD KO, and SPATA2 KO cells."
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"SPATA2 promotes CYLD activity and regulates TNF induced NF-kappaB signaling and cell death."
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"For example, SPATA2 complex with CYLD preferentially deubiquitinating the M1 ubiquitin of RIPK1. xref SPATA2 recruits CYLD to the centrosome for deubiquitination of PLK4, which attenuates NEK7 and NLRP3 interaction and further NLRP3 inflammasome activation. xref SPATA2 activates CYLD to elevate NCOA4 protein level and induces ferroptosis after doxorubicin treatment via preventing its degradation because of reducing the ubiquitination level. xref In consistent with previous reports, in this manuscript, we also found that SPATA2 inhibited β‐catenin signaling via CYLD."
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"Finally, the finding that SPATA2 activates CYLD adds SPATA2 to the growing list of allosteric DUB activators."
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"Specifically, SPATA2 recruits and activates CYLD – a deubiquitinase that attenuates TNF-induced NF-κB and mitogen-activated kinase (MAPK) signaling by removing linear and K63-linked ubiquitin chains from components of the TNF receptor signaling complex ( xref – xref )."
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"In 2016, four different groups reported SPATA2 bound to the deubiquitinase cylindromatosis (CYLD) and enhanced CYLD activity, linking SPATA2 to tumor necrosis factor α (TNF‐α) receptor related nuclear factor κB (NF‐κB), nucleotide‐binding oligomerization domain 2 (NOD2) signaling and cell death."
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"Finally, the finding that SPATA2 activates CYLD adds SPATA2 to the growing list of allosteric DUB activators."
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"The location of the SPATA2 binding site at the back of the palm domain suggests that SPATA2 activates CYLD in a distinct manner."
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"The location of the SPATA2 binding site at the back of the palm domain suggests that SPATA2 activates CYLD in a distinct manner."
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