IndraLab

Statements

SPATA2 activates CYLD. 10 / 14
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"Consistently, increased pro-inflammatory signaling in Cyld -/- Spata2 -/- cells depends on the presence of OTULIN."
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"To directly address if SPATA2 mediates the ability of CYLD to regulate baseline NF-kappaB activity, we ectopically expressed CYLD in WT, CYLD KO, and SPATA2 KO cells."
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"The location of the SPATA2 binding site at the back of the palm domain suggests that SPATA2 activates CYLD in a distinct manner."
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"SPATA2 Activates CYLD."
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"Finally, the finding that SPATA2 activates CYLD adds SPATA2 to the growing list of allosteric DUB activators."
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"SPATA2 promotes CYLD activity and regulates TNF induced NF-kappaB signaling and cell death."
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"Finally, the finding that SPATA2 activates CYLD adds SPATA2 to the growing list of allosteric DUB activators."
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"The location of the SPATA2 binding site at the back of the palm domain suggests that SPATA2 activates CYLD in a distinct manner."
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"SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling."
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"SPATA2 Activates CYLD."
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