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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 activates JNK. 2 / 2

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"However, molecules that negatively regulate Ripk1 and Jnk signaling, such as Tnfaip3 (A20) and GADD45beta respectively XREF_BIBR, are decreased in gammadelta T cells isolated from obese db/db mice."

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"However, unexpectedly, the extent and duration of TNF-induced TRAF2 recruitment into complex I was not affected by A20 overexpression ( xref , second row), indicating that suppression of TNF-induced JNK activation by A20 is independent of TRAF2 recruitment into complex I. This conjecture also seems to be consistent with the earlier observation that A20 is capable of protecting TRAF2/5 DKO MEFs against TNF-induced cell death ( xref )."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...