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Statements

Sparfloxacin inhibits KCNH2. 7 / 7
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"For example, XREF_SUPPLEMENTARY shows the development of highly asynchronous calcium transients over a 12 seconds recording at 33 Hz of NRVMs stimulated at 2 Hz after T 3 treatment in presence of hERG blocker sparfloxacin (100 microM)."
22926323
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"The comparison of potencies from grepafloxacin, moxifloxacin, and sparfloxacin to block the HERG channel shows the latter to have the greatest inhibition effect on the HERG current amplitude."
11040340
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"Sparfloxacin blocked HERG currents half-maximally (IC (50) value) at a concentration of 33.2 microM, whereas norfloxacin and lomefloxacin each tested at a concentration of 300 microM inhibited HERG currents only by 2.8 +/-3.6% and 12.3 +/-4.7%, respectively."
17027138
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"Ciprofloxacin was found to have little interaction with the HERG channel at concentrations up to 100 mug/ml, whilst sparfloxacin, grepafloxacin and moxifloxacin inhibited HERG currents with IC 50 valu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11040352
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"Sparfloxacin inhibited HERG currents with an EC 50 of 13.5 +/-0.8 mug/ml and n H of 1.3 +/-0.1."
11040340
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"Block of HERG by sparfloxacin displayed a positive voltage dependence."
11125032
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"Bath application of sparfloxacin, moxifloxacin and grepafloxacin produced an inhibition of HERG outward currents at -40 mV with EC (50) of 13.5 +/-0.8, 41."
11040340