IndraLab

Statements

Sparfloxacin inhibits KCNH2. 9 / 9
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"Fig. 1 shows an example of how sparfloxacin blocked HERG current in a concentration-dependent manner.In summary, the rank order for their effects on HERG, relative to therapeutic total plasma C max (I[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18074444
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"Fig. 1 shows an example of how sparfloxacin blocked HERG current in a concentration-dependent manner.In summary, the rank order for their effects on HERG, relative to therapeutic plasma C max (IC 50 /[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17054943
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"Ciprofloxacin was found to have little interaction with the HERG channel at concentrations up to 100 mug/ml, whilst sparfloxacin, grepafloxacin and moxifloxacin inhibited HERG currents with IC 50 valu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11040352
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"The comparison of potencies from grepafloxacin, moxifloxacin, and sparfloxacin to block the HERG channel shows the latter to have the greatest inhibition effect on the HERG current amplitude."
11040340
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"Sparfloxacin inhibited HERG currents with an EC 50 of 13.5 +/-0.8 mug/ml and n H of 1.3 +/-0.1."
11040340
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"Sparfloxacin blocked HERG currents concentration-dependently with a half-maximally inhibitory concentration (IC 50 value) of 33.2 μM (the 95% confidence interval was 25.4–43.9 μM), and the Hill coeffi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17027138
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"For example, XREF_SUPPLEMENTARY shows the development of highly asynchronous calcium transients over a 12 seconds recording at 33 Hz of NRVMs stimulated at 2 Hz after T 3 treatment in presence of hERG blocker sparfloxacin (100 microM)."
22926323
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"Drugs that primarily prolonged the QT interval through hERG channel block, including dofetilide and sparfloxacin, caused significant prolongation of oAPD as expected."
28501647
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"Block of HERG by sparfloxacin displayed a positive voltage dependence."
11125032