IndraLab

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USP13 increases the amount of LDH. 2 / 2
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"In addition, specific inhibitors of mTOR, ULK1, USP10/USP13, and ULK1/ULK2 involved in the process of autophagy, i.e., temsirolimus, SBI-0206965, spautin-1, and MRT68921 dihydrochloride, decreased LDH release to 304%, 301%, 273%, and 271% of the control, respectively (Fig. 1b)."
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"Except for temsirolimus (mTOR inhibitor), specific inhibitors of kinases ULK1 and ULK1/ULK2 (SBI-0206965 and MRT68921 dihydrochloride) as well as hydrolases USP10/USP13 (Spautin-1) involved in the process of autophagy decreased LDH release to 138%, 141%, and 134% of the control, respectively (Fig. 1a)."
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